The U.S. Food and Drug Administration (FDA) has now approved the use of colchicine, which has been used for thousands of years as an anti-inflammatory and gout treatment, to reduce cardiovascular system inflammation that causes heart attacks and strokes.
The FDA supported colchicine (Lodoco) for use by grown-ups with atherosclerosis, a thickening and solidifying of the corridors brought about by plaque development inside veins, the medication's engineer Agepha Pharma, said in a proclamation. The medication was additionally supported for grown-ups with various gamble factors for cardiovascular illness.
Statins are typically taken by high-risk patients to lower their risk of heart disease events like strokes and heart attacks, which can result in death. According to the company, compared to a placebo, statin and colchicine combination therapy can reduce the risk of death from heart disease, nonfatal heart attacks, and strokes by 31%.
According to Guillaume Marquis-Gravel, MD, an interventional cardiologist at the Montreal Heart Institute and an assistant professor at the University of Montreal, "With colchicine, we now for the first time have access to an anti-inflammatory agent that actually works, decreasing the risk of cardiovascular events, and that is also very safe to use and very affordable." Colchicine is also very safe to use.
Dr. Marquis-Gravel, who has no financial ties to Agepha Pharma, adds, "This is a real breakthrough."
Aggravation Contributes Fundamentally to Coronary failure and Stroke Chance
Researchers have known for quite a long time that irritation assumes a significant part in the improvement of atherosclerosis and its clinical results, including coronary failures and strokes, Marquis-Rock says. However, medications that were developed specifically to combat inflammation in the cardiovascular system have not been successful because they were either ineffective or had harmful side effects.
Lodoco pills containing 0.5 milligrams once daily have been approved by the FDA for use either by themselves or in conjunction with cholesterol-lowering medications like statins to combat cardiovascular system inflammation that causes atherosclerosis, heart attacks, and strokes. More than a decade ago, the FDA approved colchicine as a treatment for gout. It is also approved for familial Mediterranean fever, an inflammatory disease that causes acute abdominal, chest, and joint pain.
Colchicine Has Been Utilized for a really long time to Treat Irritation
Hundreds of years sooner, colchicine was utilized as a toxic substance in old Rome and as solution for joint torment and other provocative circumstances in old Egypt, per the Illustrious School of Doctors of Edinburgh. Research takes note of that it's gotten from the Colchicum autumnale plant, otherwise called harvest time crocus.
According to Jan Hein Cornel, MD, PhD, a professor of cardiology at Radboud University Medical Center in Alkmaar, the Netherlands, who has no financial ties to Agepha Pharma, "Colchicine is a very old drug, comes from mother nature, and was used for gout attacks until now."
Dr. Cornel adds that because inflammation plays a role in plaques eroding or breaking up inside arteries damaged by atherosclerosis, it makes sense that this ancient treatment would help prevent heart attacks and strokes. Breaking plaques have the potential to travel through blood vessels, cutting off blood supply to the heart or brain, resulting in heart attacks or strokes.
According to Cornel, "this means a tremendous step forward in the field of atherosclerotic cardiovascular disease prevention."
Agepha Pharma said Lodoco will go marked down in the final part of 2023, and didn't show how much the medication would cost.
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